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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '649da545ca347566b3df14c6609945f45694963b84b57be67be699309ebb7f34' 
  AND token = 'irZwKjsiEarxj7d4v7DWGyKbYv6aE/qi2DnM3IU7sMw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}