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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ac25ccb5ae231fa1937c1eec9e7a0bdff90831a240ace46f07d59134ffdc19' 
  AND token = 'VPjjhnBDfliysC124uka2LCWebIUEI7sq66bZOZHeuY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}