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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9ffb727932916c69d9cdd8a21ea4bb532fa06682320c8383f75d2f0bf9638c2' 
  AND token = 'USVt2um+oosyoh3CVI81cMCt9eKt2FaS642vWtmPSU0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "table": {
      "message": "Impossible WHERE noticed after reading const tables"
    }
  }
}